Optimum Shearing

DNA shearing is an experimental process used to prepare DNA for analysis or other processing by the use of mechanical instruments to randomly cleave DNA. DNA is sheared to the desired fragment range. For instance, physical shearing can be done by probe sonication and nebulization. Synonyms: Random selection by shearing.Shearing is the process of cutting sheet metal to size out of a larger roll or flat stock. As the material moves through the shear machine, cutting blades come together in order to fracture the material into separate, smaller pieces. This process creates quality clean cuts that can be repeated quickly.